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Anti-HAX1 (RABBIT) Antibody
HAX1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Host | Rabbit |
|---|---|
| Conjugate | Unconjugated |
| Target Species | Human |
| Reactivity | Rat, Human, Mouse, Chicken |
| Clonality | Polyclonal |
Application 
| WB, E, I, LCI |
| Application Note | Anti-HAX1 antibody is useful for ELISA, Immunohistochemistry, and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~35kDa corresponding to the appropriate cell lysate or extract. |
| Physical State | Liquid (sterile filtered) |
| Buffer | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Immunogen | Anti-HAX1 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region (aa190-225) of human HAX1 protein. |
| Stabilizer | 30% Glycerol |
| Gene ID | 10456 |
|---|---|
| Purity | Anti-HAX1 was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with human, rat, and mouse based on 100% sequence homology. Cross-reactivity with HAX1 from other sources has not been determined. |
| Storage Condition | Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
| Precautions Note | This product is for research use only and is not intended for therapeutic or diagnostic applications. |
| Name | HAX1 |
|---|---|
| Synonyms | HS1BP1 |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Cellular Location | Mitochondrion matrix. Endoplasmic reticulum Nucleus membrane. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O35387}. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q7TSE9}. Cytoplasm, P-body [Isoform 3]: Cytoplasm. Nucleus Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). [Isoform 5]: Cytoplasm. Note=Predominantly cytoplasmic |
| Tissue Location | Ubiquitous. Up-regulated in oral cancers. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
HAX1 is a ubiquitous protein which promotes cell survival. It is involved in the clathrin-mediated endocytosis pathway and may be involved in the internalization of ABC transporters such as ABCB11. Theoretically it inhibits CASP9 AND CASP3, and may participate in the regulation of intracellular calcium pools. Anti-Hax1 antibody is ideal for researchers interested in Apoptosis, Cancer, Metabolism, Epigenetics and Nuclear Signaling, or Cell Biology research.
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